Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Image SOCRATES (Acute Stroke Or Transient IsChaemic Attack TReated with Aspirin or Ticagrelor and Patient OutcomES) is a global clinical trial involving 9,600 patients who have experienced an acute… Furthermore, switching antithrombotic agents after stroke recurrence is a common practice that raises therapeutic dilemmas for subsequent potent antithrombotic therapy. The 2016 SOCRATES trial compared the use of ticagrelor/aspirin with aspirin monotherapy in more than 13,000 patients for secondary stroke prevention after an acute ischemic stroke or TIA. The primary endpoint ― the composite of stroke and death at 30 days ― showed "a statistically significant and clinically meaningful reduction" in the ticagrelor group, AstraZeneca announced. AstraZeneca announced that phase 3 THALES trial of ticagrelor (Brilinta) in the treatment of stroke met its primary end point, reducing the risk of the composite of stroke and death after an acute ischemic stroke (AIS) or transient ischemic attack (TIA). Background The SOCRATES study compares ticagrelor versus aspirin for the prevention of major vascular events in patients with acute ischemic stroke or transient ischemic attack [1,2]. Treatment with ticagrelor (Brilinta, AstraZeneca) plus aspirin reduced the risk of stroke and death when compared with aspirin alone, according to results from a phase 3 clinical study. There was a strong trend toward reduction of the primary end point event and ischemic stroke in the ticagrelor treatment group compared with the aspirin group. Ticagrelor tablets are indicated to reduce the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI). Brilinta, together with aspirin, has been shown to significantly reduce the risk of MACE defined as myocardial infarction (MI, heart attack), stroke or CV death, in patients with ACS or a … Medical uses. Contribution To Literature: The SOCRATES trial showed that ticagrelor monotherapy with 90 mg BID was not superior to aspirin 100 mg daily in reducing major cardiovascular events in patients presenting with low-acuity ischemic stroke or high-risk transient ischemic attack (TIA). 2017 Jan;48(1):167-173. doi: 10.1161/STROKEAHA.116.014891. Epub 2016 Nov 29. Background The SOCRATES study compares ticagrelor versus aspirin for the prevention of major vascular events in patients with acute ischemic stroke or transient ischemic attack [1,2]. Brilinta (ticagrelor) is an oral, reversible, direct-acting P2Y12 receptor antagonist that works by inhibiting platelet activation. In it, ticagrelor was shown to be nonsuperior to aspirin for the prevention of stroke (ischemic or hemorrhagic), myocardial infarction, or death at 90 days of treatment.

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