3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer. Fyffe C(1), Falasca M. Author information: (1)Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signallling Group, London, UK. 3-Phosphoinositide-dependent protein kinase 1 (PDPK1), a serine–threonine kinase, is a master kinase that is crucial for phosphorylating and activating a subgroup of the AGC family of protein kinases. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) SAAS (System generated rules) Supporting data. 3-phosphoinositide-dependent protein kinase 1 (PDPK1), an oncogenic serine–threonine protein kinase, is commonly expressed in its phosphorylated active form in patient-derived tumor cells of various types of B-cell NHL cells, including diffuse large B-cell lymphoma, follicular lymphoma, and MCL. PDK1 (3-Phosphoinositide-dependent kinase 1) is a key member of the AGC protein kinase family. Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. 3-Phosphoinositide-dependent kinase 1 (PDK1) has been identified as the activating kinase that phosphorylates PKB in a PI 3-kinase dependent process at Thr 308 in vitro and in vivo (see Figure 1).This protein serine/threonine kinase also has a PH domain that specifically binds PtdIns(3,4,5)P 3 and PI(3,4)P 2 and is found both in the cytosol and on the plasma membrane. 3-phosphoinositide-dependent protein kinase 1, Pkb kinase.

View protein in InterPro IPR011009 Kinase-like_dom_sf IPR033931 PDK1-typ_PH IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS Pfam i View protein in Pfam PF14593 PH_3, 1 hit PF00069 Pkinase, 1 hit 3-Phosphoinositide-Dependent Protein Kinase-1/Akt Signaling Represents a Major Cyclooxygenase-2-Independent Target for Celecoxib in Prostate Cancer Cells | Cancer Research It plays an important role in a variety of cellular functions, leading to the activation of the PI3K signaling pathway, an event often associated with the onset and progression of several human cancers. Annotation systems. 3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.pdf Available via license: CC BY-NC 3.0 Content may be subject to copyright. Protein sets from fully sequenced genomes. Mechanistically, it targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT and was associated with patient survival after targeted therapies… 3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer Chanse Fyffe and Marco Falasca Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signallling Group, London, UK Together, these data underscore the role of 3-phosphoinositide-dependent protein kinase-1/Akt signaling in celecoxib-mediated in vitro antiproliferative effects in prostate cancer cells. 3-Phosphoinositide-dependent kinase 1 (PDK1) has been identified as the activating kinase that phosphorylates PKB in a PI 3-kinase dependent process at Thr 308 in vitro and in vivo (see Figure 1).This protein serine/threonine kinase also has a PH domain that specifically binds PtdIns(3,4,5)P 3 and PI(3,4)P 2 and is found both in the cytosol and on the plasma membrane. Different actors of the PI 3-kinase cascade have been identified as critical control points in insulin signaling , among them 3′-phosphoinositide–dependent protein kinase-1 (PDK1).

These findings imply that the disruption of metabolism and impaired mitochondrial activity might be involved in the pathogenesis of heart failure with PDK1 (PDPK1) deletion. This kinase was initially recognized by its ability to phosphorylate in the presence of lipid products generated by PI 3-kinase, the activation loop of PKB on Thr-308 ( 10 , 11 ). GeneRIFs: Gene References Into Functions. View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

This section displays by default the canonical protein sequence and upon request all isoforms described in the entry.

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